Upregulation of lysine-specific demethylase 6B aggravates inflammatory pain through H3K27me3 demethylation-dependent production of TNF-α in the dorsal root ganglia and spinal dorsal horn in rats.
Yiming QiaoLiren LiLiying BaiYan GaoYin YangLi WangXueli WangZongyi LiangJi-Tian XuPublished in: CNS neuroscience & therapeutics (2023)
These results suggest that upregulated KDM6B via facilitating TNF-α expression in the DRG and spinal dorsal horn aggravates inflammatory pain.