Altered bone-regulating myokine expression in skeletal muscle Of Duchenne muscular dystrophy mouse models.

Shumin ZhouBaoli QianLing WangChangqing ZhangMacalus V HoganHongshuai Li

Published in: Muscle & nerve (2018)

Dystrophic skeletal muscle demonstrated a significantly altered myokine gene expression profile. mRNA and protein levels of several bone-regulating myokines were significantly altered in dystrophic skeletal muscle, which suggests pathological role of bone-regulating myokines on bone homeostasis in DMD. Muscle Nerve 58: 573-582, 2018.

Keyphrases

skeletal muscle
duchenne muscular dystrophy
bone mineral density
insulin resistance
soft tissue
bone loss
bone regeneration
mouse model
poor prognosis
postmenopausal women
adipose tissue
metabolic syndrome
muscular dystrophy
copy number
small molecule
protein protein
dna methylation