Synergistic Antimicrobial Glycyrrhizic Acid-based Functional Biosensing composite for Sensitive Glucose Monitoring and Collaborative Wound Healing.

High glucose blood and bacterial infection remain major issues for the slow healing of diabetic wounds, so developing functional biosensing composite with excellent antibacterial and remarkable glucose response sensitivity is necessary and prospective. Herein, by in situ synthesis AgNPs on the surface of self-prepared PTIGA elastomers, PTIGA-AgNPs conductive composites were obtained with efficient synergistic antibacterial effect, excellent mechanical, and self-healing properties. The strain of the composites could reach 1800%, and its self-healing efficiency exceeded 90% at 60 °C within 8 hours. Both elastomers and composites represented excellent biocompatibility and the antibacterial rate against E coli and S aureus exceeded 90%. Moreover, the biosensor assembled from the conductive composites exhibited excellent glucose response sensitivity and stability, with a sensitivity coefficient (SC) of 0.518 mA mM -1 in the range of 0.2-3.6 mM glucose concentration, as well as a low detection limit (DL) of 0.08 mM. Furthermore, based on the remarkable antibacterial performance and bioactivity derived from GA, the composites reduced the expression of pro-inflammatory factors and promoted the production of anti-inflammatory factors, and effectively promoted the regeneration of skin and granulation tissue of wounds in a diabetic full-thickness skin defect model, demonstrating the enormous therapeutic potential in diabetic wound healing. This article is protected by copyright. All rights reserved.