Drugs for treating infections caused by non-tubercular mycobacteria: a narrative review from the study group on mycobacteria of the Italian Society of Infectious Diseases and Tropical Medicine.
Andrea CalcagnoLoredana SarmatiL SarmatiM TadoliniR ParrellaA MatteelliNiccolò RiccardiMichele TrezziAntonio Di BiagioV PirriatoreA RussoG GualanoEmanuele PontaliL SuraceE FalboJ MencariniF PalmieriAndrea GoriM SchiumaGiuseppe LapadulaDelia Golettinull nullPublished in: Infection (2024)
This review aims at describing the drugs used for treating NTM-associated diseases emphasizing the efficacy, tolerability, optimization strategies as well as possible drugs that might be used in case of intolerance or resistance. We also reviewed data on newer compounds highlighting the lack of randomised clinical trials for many drugs but also encouraging preliminary data for others. We also focused on non-pharmacological interventions that need to be adopted during care of individuals with NTM-associated diseases CONCLUSIONS: Despite insufficient efficacy and poor tolerability this review emphasizes the improvement in patients' care and the needs for future studies in the field of anti-NTM treatments.
Keyphrases
- clinical trial
- open label
- infectious diseases
- healthcare
- palliative care
- end stage renal disease
- electronic health record
- ejection fraction
- double blind
- newly diagnosed
- quality improvement
- chronic kidney disease
- placebo controlled
- big data
- randomized controlled trial
- climate change
- drug induced
- prognostic factors
- study protocol
- chronic pain
- artificial intelligence
- data analysis
- case control
- patient reported