Peak Inspiratory Flow Rate in COPD: An Analysis of Clinical Trial and Real-World Data.
Martin AndersonKathryn CollisonM Bradley DrummondMelanie HamiltonRenu G JainNeil MartinRichard A MularskiMike ThomasChang-Qing ZhuGary T FergusonPublished in: International journal of chronic obstructive pulmonary disease (2021)
Nearly all COPD patients in the 207608/207609 and KPNW populations achieved spirometric PIF values estimated as equivalent to PIFR of ≥30 L/min through the ELLIPTA DPI. Lack of correlation between spirometric PIF at screening and treatment efficacy aligns with consistent dose performance from the ELLIPTA DPI across a wide range of PIFs, achieved by patients with COPD of all severities.
Keyphrases
- chronic obstructive pulmonary disease
- lung function
- clinical trial
- end stage renal disease
- chronic kidney disease
- newly diagnosed
- ejection fraction
- peritoneal dialysis
- prognostic factors
- electronic health record
- cystic fibrosis
- randomized controlled trial
- open label
- machine learning
- big data
- study protocol
- phase iii
- replacement therapy
- genetic diversity