Fgf8 dosage regulates jaw shape and symmetry through pharyngeal-cardiac tissue relationships.
Nathaniel ZbasnikKatie DolanStephanie A BuczkowskiRebecca M GreenBenedikt HallgrimssonRalph S MarcucioAnne M MoonJennifer L FishPublished in: Developmental dynamics : an official publication of the American Association of Anatomists (2022)
We hypothesize that these asymmetries are linked to heart development resulting in higher levels of Fgf8 on the right side of the face, which may buffer the right side to developmental perturbations. This mouse model may facilitate future investigations of mechanisms underlying human syngnathia and facial asymmetry.