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A human monoclonal antibody blocking SARS-CoV-2 infection.

Chunyan WangWentao LiDubravka DrabekNisreen M A OkbaRien van HaperenAlbert D M E OsterhausFrank J M van KuppeveldBart L HaagmansFrank GrosveldBerend-Jan Bosch
Published in: Nature communications (2020)
The emergence of the novel human coronavirus SARS-CoV-2 in Wuhan, China has caused a worldwide epidemic of respiratory disease (COVID-19). Vaccines and targeted therapeutics for treatment of this disease are currently lacking. Here we report a human monoclonal antibody that neutralizes SARS-CoV-2 (and SARS-CoV) in cell culture. This cross-neutralizing antibody targets a communal epitope on these viruses and may offer potential for prevention and treatment of COVID-19.
Keyphrases
  • sars cov
  • monoclonal antibody
  • respiratory syndrome coronavirus
  • endothelial cells
  • coronavirus disease
  • pluripotent stem cells
  • drug delivery
  • combination therapy
  • climate change
  • cancer therapy
  • human health