Intracellular labile iron is a key regulator of hepcidin expression and iron metabolism.

Yanmeng LiQin OuyangZhibin ChenWei ChenBei ZhangSong ZhangMin CongAnjian Xu

Published in: Hepatology international (2022)

Our findings reveal the importance of intracellular labile iron in iron metabolism, and propose that TNFα might be a novel therapeutic target for HFE-associated hemochromatosis.

Keyphrases

iron deficiency
poor prognosis
rheumatoid arthritis
reactive oxygen species
transcription factor
gene expression
binding protein