The association between depressive symptoms and insulin resistance, inflammation and adiposity in men and women.
M'Balu A WebbMelanie DaviesNuzhat AshraDanielle BodicoatEmer BradyDavid WebbCalum MoultonKhalida IsmailKamlesh KhuntiPublished in: PloS one (2017)
Depressive symptoms are associated with metabolic derangements. Whilst women tended to show elevations in biomarkers related to an increased risk of type 2 diabetes (HOMA IR, leptin and TNF-α), men showed a marked increase in the cardiovascular disease risk biomarker CRP. However, perhaps due to the cohort size, interaction analysis did not show a significant gender difference.
Keyphrases
- depressive symptoms
- insulin resistance
- polycystic ovary syndrome
- cardiovascular disease
- social support
- type diabetes
- adipose tissue
- sleep quality
- rheumatoid arthritis
- oxidative stress
- high fat diet
- metabolic syndrome
- skeletal muscle
- mental health
- middle aged
- pregnancy outcomes
- high fat diet induced
- breast cancer risk
- cardiovascular risk factors
- body mass index
- pregnant women
- weight loss
- data analysis