Diagnostic potential of sarcoplasmic myxovirus resistance protein A expression in subsets of dermatomyositis.

Akinori UruhaY AllenbachJ-L CharuelL MussetA AussyOlivier BoyerK MariampillaiO Landon-CardinalC RasmussenL BolkoT MaisonobeS Leonard-LouisS SuzukiI NishinoWerner StenzelO Benveniste

Published in: Neuropathology and applied neurobiology (2018)

Sarcoplasmic MxA expression is more sensitive than PFA and RIG-I expression for a pathological diagnosis of DM, regardless of the autoantibody-related subgroup. In light of its high sensitivity and specificity, it may be considered a pathological hallmark of DM per se. Also, lack of MxA expression in ASS supports the idea that ASS is a distinct entity from DM.

Keyphrases

poor prognosis
type diabetes
risk assessment
metabolic syndrome
weight loss
drug induced