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Clinical and genetic characteristics of late-onset Huntington's disease in a large European cohort.

Martina PetraccaSonia Di TellaMarcella SolitoPaola ZinziMaria Rita Lo MonacoGiulia Di LazzaroPaolo CalabresiMaria Caterina SilveriAnna Rita Bentivoglio
Published in: European journal of neurology (2022)
It is likely that cognitive disorders and motor symptoms of LoHD are at least partly age-related and not a direct expression of the disease. In addition to CAG-triplet repeat expansion, future studies should investigate the role of other genetic and environmental factors in determining age of onset.
Keyphrases
  • late onset
  • early onset
  • genome wide
  • poor prognosis
  • dna methylation
  • current status
  • gene expression
  • binding protein
  • long non coding rna
  • sleep quality
  • case control