Clinical and genetic characteristics of late-onset Huntington's disease in a large European cohort.
Martina PetraccaSonia Di TellaMarcella SolitoPaola ZinziMaria Rita Lo MonacoGiulia Di LazzaroPaolo CalabresiMaria Caterina SilveriAnna Rita BentivoglioPublished in: European journal of neurology (2022)
It is likely that cognitive disorders and motor symptoms of LoHD are at least partly age-related and not a direct expression of the disease. In addition to CAG-triplet repeat expansion, future studies should investigate the role of other genetic and environmental factors in determining age of onset.