Genomic Profiling Identifies Association of IDH1/IDH2 Mutation with Longer Relapse-Free and Metastasis-Free Survival in High-Grade Chondrosarcoma.
Guo Gord ZhuKhedoudja NafaNarasimhan AgaramAhmet ZehirRyma BenayedJustyna SadowskaLaetitia BorsuCiara KellyWilliam D TapNicola FabbriEdward AthanasianPatrick J BolandJohn H HealeyMichael F BergerMarc LadanyiMeera HameedPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2019)
IDH1/IDH2 mutations are associated with longer relapse-free and metastasis-free survival in high-grade chondrosarcomas, and they tend to co-occur with TERT mutations and with CDKN2A/2B and TP53 alterations in a subset of high-grade chondrosarcomas.