Polyunsaturated fatty acid-derived IKs channel activators shorten the QT interval ex-vivo and in-vivo.
Mark Alexander SkarsfeldtSara I LiinHans P LarssonBo Hjorth BentzenPublished in: Acta physiologica (Oxford, England) (2020)
Our results show that specific PUFAs shorten QT interval in guinea pig hearts. The tendency of modified PUFAs with pronounced IKs channel activating effect to better restore QT interval suggests that modifying PUFAs to target the IKs channel is a means to improve the QT-shortening effect.
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