Human Recombinant Apyrase Therapy Protects Against Myocardial Ischemia/Reperfusion Injury and Preserves Left Ventricular Systolic Function in Rats, as Evaluated by 7T Cardiovascular Magnetic Resonance Imaging.
Ziqian XuWei ChenRu-Zhi ZhangLei WangRidong ChenJie ZhengFabao GaoPublished in: Korean journal of radiology (2020)
APT102 can significantly alleviate damage to the ischemic myocardium and microvasculature. IMH size peaked at 48 hours post reperfusion and IMH is a downstream consequence of MVO. IMH may be a potential therapeutic target to prevent adverse remodeling in MI.
Keyphrases
- left ventricular
- ischemia reperfusion injury
- magnetic resonance imaging
- acute myocardial infarction
- oxidative stress
- hypertrophic cardiomyopathy
- heart failure
- endothelial cells
- cerebral ischemia
- cardiac resynchronization therapy
- left atrial
- aortic stenosis
- mitral valve
- pluripotent stem cells
- blood pressure
- induced pluripotent stem cells
- computed tomography
- acute ischemic stroke
- emergency department
- cell free
- subarachnoid hemorrhage
- human health
- risk assessment
- stem cells
- climate change
- mesenchymal stem cells
- magnetic resonance
- brain injury
- adverse drug
- electronic health record
- atrial fibrillation
- catheter ablation