Circulating mitochondrial DNA copy numbers represent a sensitive marker for diagnosis and monitoring of disease activity in systemic lupus erythematosus.
Stavros GiaglisDouglas DaoudlarianReinhard E VollDiego KyburzNils VenhoffUlrich A WalkerPublished in: RMD open (2022)
Circulating mtDNA unlike nDNA molecules are markedly increased in SLE plasma. Regardless of disease activity, circulating mtDNA levels distinguish patients with SLE from healthy controls with high sensitivity and represent an independent marker of SLE activity.