Autoimmune hepatitis displays distinctively high multi-antennary sialylation on plasma N-glycans compared to other liver diseases.

Tamas Pongracz Maaike Biewenga Anna Eva Charlotte Stoelinga Marco René Bladergroen Simone Nicolardi Leendert Adrianus Trouw Dana L E Vergoossen Noortje de Haan Bart van Hoek

Published in: Journal of translational medicine (2024)

Compared to other liver diseases, AIH shows distinctively high A4GS levels in plasma, with potential implications on glycoprotein function and clearance. Plasma-derived glycosylation has potential to be used as a diagnostic marker for AIH in the future. This may alleviate the need for a liver biopsy at diagnosis. Glycosidic changes should be investigated further in longitudinal studies and may be used for diagnostic and monitoring purposes in the future.

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