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A Bayesian adaptive design approach for stepped-wedge cluster randomized trials.

Jijia WangJing CaoChul AhnSong Zhang
Published in: Clinical trials (London, England) (2024)
This study presents the incorporation of Bayesian adaptive strategies into stepped-wedge cluster randomized trials design. The proposed approach provides the flexibility to stop the trial early if substantial evidence of efficacy or futility is observed, improving the flexibility and efficiency of stepped-wedge cluster randomized trials.
Keyphrases
  • study protocol
  • randomized controlled trial
  • clinical trial
  • phase iii
  • open label