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Re-adjudication of the Trial Evaluating Cardiovascular Outcomes with Sitagliptin (TECOS) with study-level meta-analysis of hospitalization for heart failure from cardiovascular outcomes trials with dipeptidyl peptidase-4 (DPP-4) inhibitors.

Benjamin M SciricaKyungAh ImSabina A MurphyJulia F KuderDolly A RodriguezRenato D LopesJennifer B GreenChristian T RuffMarc S Sabatine
Published in: Clinical cardiology (2022)
The results of this independent re-adjudication process and analyses of CV outcomes from TECOS were consistent with the original adjudication results and overall study findings. An updated study-level meta-analysis showed no overall significant risk for HHF with DPP-4 inhibitors, but with statistical heterogeneity.
Keyphrases
  • heart failure
  • systematic review
  • clinical trial
  • randomized controlled trial
  • atrial fibrillation
  • meta analyses
  • case control
  • breast cancer risk