Three Distinct Stroma Types in Human Pancreatic Cancer Identified by Image Analysis of Fibroblast Subpopulations and Collagen.
Yurina OgawaYohei MasugiTokiya AbeKen YamazakiAkihisa UenoYoko Fujii-NishimuraShutaro HoriHiroshi YagiMinoru KitagoMichiie SakamotoPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2020)
This study identified three distinct stroma types differentially associated with survival, immunity, and molecular features, thereby underscoring the importance of stromal heterogeneity in subtyping pancreatic cancers and supporting the development of antistromal therapies.