Gdf11 gene transfer prevents high fat diet-induced obesity and improves metabolic homeostasis in obese and STZ-induced diabetic mice.

Bingxin LuJianing ZhongJianfei PanXiaopeng YuanMingzhi RenLiping JiangYuqing YangGuisheng ZhangDexi LiuChunbo Zhang

Published in: Journal of translational medicine (2019)

These results demonstrate that GDF11 plays an important role in regulating metabolic homeostasis and energy balance and could be a target for pharmacological intervention to treat metabolic disease.

Keyphrases

high fat diet induced
insulin resistance
metabolic syndrome
weight loss
diabetic rats
type diabetes
adipose tissue
randomized controlled trial
genome wide
copy number
weight gain
gene expression
body mass index
bariatric surgery
drug induced
transcription factor
mouse model
obese patients