Supplementation with autologous adipose stem cell-derived mitochondria can be a safe and promising strategy for improving oocyte quality.
Udayanga Sanath Kankanam GamageShu HashimotoYuki MiyamotoTatsuya NakanoMasaya YamanakaHideki KitajiYuki TakadaHiroshi MatsumotoAkiko KoikeManabu SatohMasako IchishiMasatoshi WatanabeYoshiharu MorimotoPublished in: Journal of assisted reproduction and genetics (2024)
Injection of ASC-mitochondria into oocytes may be a promising technique to support developmental potential without causing adverse epigenetic events in the offspring in mice. However, before considering clinical application, additional safety screening using larger animals or non-human primates is essential.
Keyphrases
- stem cells
- endothelial cells
- cell death
- reactive oxygen species
- endoplasmic reticulum
- dna methylation
- gene expression
- adipose tissue
- cell therapy
- high fat diet
- induced pluripotent stem cells
- bone marrow
- insulin resistance
- pluripotent stem cells
- ultrasound guided
- human health
- nlrp inflammasome
- quality improvement
- metabolic syndrome
- adverse drug
- climate change
- wild type