Immunological impact of tetrahydrobiopterin on the central nervous system in a murine model of rabies virus infection.
Caio Vinicius Botelho BritoÉrika Dayane Leal RodriguesFernanda Monik Silva MartinsLavinia Dias TavaresAndré Luis de Sousa Nogueira LimaLucas Carvalho FerreiraCarlos Junior Lopes SantanaJoão Augusto Gomes de Souza Monteiro de BritoLívia Medeiros Neves CassebJosé Antonio Picanço Diniz JuniorPublished in: Revista do Instituto de Medicina Tropical de Sao Paulo (2021)
Currently, the Milwaukee protocol presents healing results in human beings affected by the rabies virus. However, there are many points to clarify on the action of drugs and the immune mechanism involved in the evolution of the disease. One of the drugs used is biopterin, which is an important cofactor for nitric oxide, important for preventing vasospasm. Thus, we describe the effect of biopterin on some inflammatory factors in a rabies virus infection developed in an animal model. The immunological mediators studied in animals infected with rabies virus submitted to doses of sapropterin were Anti-RABV, IL-6, IL-2, IL-17a, INF-gamma and Anti-iNOS. It is suggested that the medication in the context of a RABV infection already installed, had the effect of modulating the inflammatory mechanisms mainly linked to the permeability of the blood-brain barrier and the migration of cytotoxic cells.
Keyphrases
- nitric oxide
- endothelial cells
- induced apoptosis
- oxidative stress
- nitric oxide synthase
- randomized controlled trial
- subarachnoid hemorrhage
- signaling pathway
- cell cycle arrest
- emergency department
- induced pluripotent stem cells
- cell proliferation
- cerebrospinal fluid
- endoplasmic reticulum stress
- brain injury
- anti inflammatory