Niclosamide Enema for Active Distal Ulcerative Colitis: A Phase 1, Open-Label Study.

Irene MarafiniElena De CristofaroSilvia SalvatoriEmma CalabreseElisabetta LolliIvan MonteleoneLuigi FranchiRachele CiccocioppoGary GlickAnthony OpipariGiovanni Monteleone

Published in: Inflammatory bowel diseases (2023)

Niclosamide enema treatment is safe and well tolerated. Niclosamide improves clinical symptoms and endoscopic/histologic signs of UC; however, appropriately designed placebo-controlled clinical trials are required to confirm efficacy.

Keyphrases

clinical trial
open label
phase ii
ulcerative colitis
phase iii
placebo controlled
double blind
study protocol
phase ii study
ultrasound guided
minimally invasive
randomized controlled trial
radiation therapy
sleep quality
combination therapy
rectal cancer