Glucose-6-phosphate dehydrogenase correlates with tumor immune activity and programmed death ligand-1 expression in Merkel cell carcinoma.

Motoki NakamuraKotaro NagaseMaki YoshimitsuTetsuya MagaraYuka NojiriHiroshi KatoTadahiro KobayashiYukiko TeramotoMasahito YasudaHidefumi WadaToshiyuki OzawaYukie UmemoriDai OgataAkimichi Morita

Published in: Journal for immunotherapy of cancer (2021)

G6PD expression was an immunohistochemically and serum-detectable prognostic marker that negatively correlated with immune activity and PD-L1 levels, and could be used to predict the immunotherapy response.

Keyphrases

poor prognosis
long non coding rna
type diabetes
blood pressure
blood glucose
skeletal muscle
insulin resistance