AMPK activation modulates IL-36-induced inflammatory responses by regulating IκBζ expression in the skin.
Yi-Ting HuangLing-Ya ChiuPo-Hsuan LuPa-Fan HsiaoJen-Yu WangPing-Hsun LuNan-Lin WuPublished in: British journal of pharmacology (2024)
AMPK activation suppresses IL-36-induced IL-8 and CCL20 release by regulating IκBζ expression in keratinocytes and reduces IL-36-induced skin inflammation in mice, suggesting that AMPK activation is a potential strategy for treating patients with IL-36-mediated inflammatory skin disorders.