KAP1 stabilizes MYCN mRNA and promotes neuroblastoma tumorigenicity by protecting the RNA m 6 A reader YTHDC1 protein degradation.

Yi YangYingwen ZhangGuoyu ChenBowen SunFei LuoYijin GaoHaizhong FengYanxin Li

Published in: Journal of experimental & clinical cancer research : CR (2024)

A modification by STM2457, a small-molecule inhibitor of METTL3, could downregulate MYCN expression and attenuate tumor proliferation. This finding provides a new alternative putative therapeutic strategy for MYCN-amplified NB.

Keyphrases

small molecule
protein protein
binding protein
poor prognosis
signaling pathway
amino acid
nucleic acid