The pathological roles of NDRG2 in Alzheimer's disease, a study using animal models and APPwt-overexpressed cells.

Xian-Fang RongYing-Ni SunDong-Mei LiuHua-Jing YinYing PengShao-Feng XuLing WangXiao-Liang Wang

Published in: CNS neuroscience & therapeutics (2017)

Our study confirmed the upregulation of NDRG2 in AD animal models and demonstrated its important roles in AD pathology. NDRG2 might be a potential target for studying and treatment of AD.

Keyphrases

induced apoptosis
poor prognosis
signaling pathway
cell proliferation
cognitive decline
endoplasmic reticulum stress
oxidative stress
long non coding rna
human health
mild cognitive impairment