Response-shift effects in neuromyelitis optica spectrum disorder: a secondary analysis of clinical trial data.
Carolyn Emily SchwartzRoland B StarkBrian D StuckyPublished in: Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation (2020)
Trial patients experienced response shifts related to treatment- and relapse-related experiences. Published trial results likely under-estimated Eculizumab vs. Placebo differences due to recalibration and reconceptualization, and relapse effects due to recalibration, reprioritization, and reconceptualization. This novel random-effects- model application builds on response-shift theory and provides a small-sample method for better estimating treatment effects in clinical trials.