Parental Occupational Exposure and Neurodevelopmental Disorders in Offspring: a Systematic Review and Meta-analysis.
Maryam BemanalizadehMehri KhoshhaliParvin GoliIbrahim AbdollahpourRoya KelishadiPublished in: Current environmental health reports (2022)
In the meta-analysis of 20 included studies, significant associations were found between parental occupational exposure to pesticides or solvents and the risk of attention deficit hyperactivity disorder in offspring. Prenatal occupational exposure to pesticides was significantly associated with motor development or cognition disorders in children. Furthermore, some evidence showed that metals might have a role in the development of autism spectrum disorders. Further studies need to identify the level of parental occupational exposures that can be significantly associated with NDDs. Moreover, utilizing standardized outcome and exposure scales is recommended to incorporate paternal, maternal, and parental as well as both prenatal and postnatal exposure in future studies.
Keyphrases
- attention deficit hyperactivity disorder
- case control
- autism spectrum disorder
- systematic review
- pregnant women
- risk assessment
- high fat diet
- young adults
- randomized controlled trial
- meta analyses
- adipose tissue
- body mass index
- white matter
- gas chromatography
- physical activity
- skeletal muscle
- mass spectrometry
- current status
- high resolution
- drinking water
- pregnancy outcomes
- weight loss
- simultaneous determination