Ursolic Acid Lactone Obtained from Eucalyptus tereticornis Increases Glucose Uptake and Reduces Inflammatory Activity and Intracellular Neutral Fat: An In Vitro Study.
Norman BalcazarLaura I BetancurDiana L MuñozFrankly J CabreraAdriana CastañoFernando L EcheverriSergio AcinPublished in: Molecules (Basel, Switzerland) (2021)
Obesity has a strong relationship to insulin resistance and diabetes mellitus, a chronic metabolic disease that alters many physiological functions. Naturally derived drugs have aroused great interest in treating obesity, and triterpenoids are natural compounds with multiple biological activities and antidiabetic mechanisms. Here, we evaluated the bioactivity of ursolic acid lactone (UAL), a lesser-known triterpenoid, obtained from Eucalyptus tereticornis. We used different cell lines to show for the first time that this molecule exhibits anti-inflammatory properties in a macrophage model, increases glucose uptake in insulin-resistant muscle cells, and reduces triglyceride content in hepatocytes and adipocytes. In 3T3-L1 adipocytes, UAL inhibited the expression of genes involved in adipogenesis and lipogenesis, enhanced the expression of genes involved in fat oxidation, and increased AMP-activated protein kinase phosphorylation. The range of biological activities demonstrated in vitro indicates that UAL is a promising molecule for fighting diabetes.
Keyphrases
- insulin resistance
- high fat diet induced
- adipose tissue
- protein kinase
- glycemic control
- type diabetes
- blood glucose
- poor prognosis
- high fat diet
- skeletal muscle
- metabolic syndrome
- polycystic ovary syndrome
- anti inflammatory
- induced apoptosis
- weight loss
- cardiovascular disease
- cell cycle arrest
- oxidative stress
- liver injury
- drug induced
- long non coding rna
- weight gain
- cell death
- blood pressure
- visible light
- reactive oxygen species
- cell proliferation