CD177 drives the transendothelial migration of Treg cells enriched in human colorectal cancer.

Shouyu KeYi LeiYixian GuoFeng XieYimeng YuHaigang GengYiqing ZhongDanhua XuXu LiuFengrong YuXiang XiaZizhen ZhangChunchao ZhuWei LingBin LiWenyi Zhao

Published in: Clinical & translational immunology (2024)

These results demonstrated that Treg cells with higher CD177 levels exhibited an enhanced activation status and transendothelial migration capacity. Our findings suggest that CD177 may serve as an immunotherapeutic target and that overexpression of CD177 may improve the efficacy of chimeric antigen receptor T (CAR-T) cell therapy.

Keyphrases

cell therapy
induced apoptosis
cell cycle arrest
nk cells
stem cells
cell proliferation
endoplasmic reticulum stress
signaling pathway
oxidative stress
pluripotent stem cells