Comprehensive Analysis of Human Epidermal Growth Factor Receptor 2 Through DNA, mRNA, and Protein in Diverse Malignancies.

Akram Mesleh Shayeb Razelle Kurzrock Jacob J Adashek Shumei Kato

Published in: JCO precision oncology (2023)

We demonstrate variability of HER2 (protein and mRNA) expression and amplification using comprehensive assays (CNV, mRNA, and IHC) among diverse cancers. As HER2-targeted therapy indications expand, the relative importance of these modalities merits further evaluation.

Keyphrases

epidermal growth factor receptor
binding protein
tyrosine kinase
advanced non small cell lung cancer
endothelial cells
protein protein
nucleic acid
amino acid
circulating tumor
single molecule
cell free
small molecule
young adults
pluripotent stem cells