Long non-coding RNAs: a valuable biomarker for metabolic syndrome.
Mohammad RashidmayvanReza SahebiMajid Ghayour-MobarhanPublished in: Molecular genetics and genomics : MGG (2022)
Long non-coding RNAs (lncRNAs) have become important regulators of gene expression because they affect a wide range of biological processes, such as cell growth, death, differentiation, and aging. More and more evidence suggests that lncRNAs play a role in maintaining metabolic homeostasis. When certain lncRNAs are out of balance, metabolic disorders like diabetes, obesity, and heart disease get worse. In this review, we talk about what we know about how lncRNAs control metabolism, with a focus on diseases caused by long-term inflammation and the characteristics of the metabolic syndrome. We looked at lncRNAs and their molecular targets in the pathogenesis of signaling pathways. We also talked about how lncRNAs are becoming more and more interesting as diagnostic and therapeutic targets for improving metabolic homeostasis.
Keyphrases
- long non coding rna
- metabolic syndrome
- network analysis
- gene expression
- genome wide identification
- poor prognosis
- genome wide analysis
- insulin resistance
- type diabetes
- cardiovascular disease
- signaling pathway
- transcription factor
- pulmonary hypertension
- cardiovascular risk factors
- glycemic control
- adipose tissue
- weight gain
- skeletal muscle