Modulatory effect of long-term treatment with escitalopram and clonazepam on the expression of anxiety-related neuropeptides: neuromedin U, neuropeptide S and their receptors in the rat brain.

Aneta Piwowarczyk-Nowak Artur Pałasz Katarzyna Bogus Marek Krzystanek Iwona Błaszczyk John J Worthington Aniela Grajoszek

Published in: Molecular biology reports (2022)

Pharmacological effects of escitalopram may be connected with local at least partially NPSR-related alterations in the NPS/NMU/NMUR2 gene expression at the level selected rat brain regions. A novel alternative mode of SSRI action can be therefore cautiously proposed.

Keyphrases

gene expression
major depressive disorder
poor prognosis
dna methylation
binding protein
combination therapy