Fludrocortisone dose-response relationship in septic shock: a randomised phase II trial.
James WalshamNaomi E HammondAntje BlumenthalJeremy CohenJohn A MyburghSimon R FinferDavid M EvansSandra L PeakePeter S KrugerJames McCulloughLoki JohnkDhaval GhelaniLaurent BillotSana ShanJason MeyerDorrilyn RajbhandariCarolyn KochRinaldo BellomoLouise M BurrellMorag J YoungMichael S RobertsLorraine MackenzieGregory MedleyJoshua DaltonBalasubramanian VenkateshPublished in: Intensive care medicine (2024)
Enteral fludrocortisone resulted in detectable plasma fludrocortisone concentrations in the majority of critically ill patients with septic shock, although they varied widely indicating differing absorption and bioavailability. Its addition to hydrocortisone was not associated with shorter time to shock resolution.