Sorbitol Destroyed Intestinal Microfold Cells (M Cells) Development through Inhibition of PDE4-Mediated RANKL Expression.

Li XiangWenxu PanHuan ChenWenjun DuShuping XieXinhua LiangFangying YangRongwei NiuCanxin HuangMinan LuoYuxin XuLanlan GengSitang GongWanfu Xu Junhong Zhao

Published in: Mediators of inflammation (2024)

These findings suggested that sorbitol suppressed intestinal enteroids and M-cell differentiation and matured through PDE4-mediated RANKL expression; targeting to inhibit PDE4 was sufficient to induce M-cell development.

Keyphrases

induced apoptosis
poor prognosis
cell cycle arrest
endoplasmic reticulum stress
stem cells
nuclear factor
cell death
cell proliferation
bone loss
mesenchymal stem cells
bone marrow
cancer therapy
long non coding rna