Longitudinal Shifts of Solid Tumor and Liquid Biopsy Sequencing Concordance in Metastatic Breast Cancer.
Minetta C LiuMatthew MacKayMatthew KaseAneta PiwowarczykChristine LoJeff SchaefferJustin D FinkleChristopher E MasonNike BeaubierKimberly L BlackwellBen Ho ParkPublished in: JCO precision oncology (2022)
We observed high concordances between tissue and cfDNA results that generally decreased with longer durations between tests. Thus, cfDNA NGS reliably measures tissue genomics and is likely beneficial for longitudinal monitoring of molecular changes in mBC.