Rho-associated protein kinase 1 inhibition in hepatocytes attenuates nonalcoholic steatohepatitis.
Ester DohnalkovaRachel L BayerQianqian GuoAdebowale O BamideleHyun Se Kim LeeLucía Valenzuela-PérezAnuradha KrishnanKevin D PavelkoNicolas E S GuisotPeter BunyardYoung-Bum KimSamar H IbrahimGregory J GoresPetra HirsovaPublished in: Hepatology communications (2023)
Genetic or pharmacologic inhibition of ROCK1 activity attenuates murine NASH, suggesting that ROCK1 may be a therapeutic target for treating human NASH.