Upregulation of Cellular Palmitoylation Mitigates α-Synuclein Accumulation and Neurotoxicity.

Gary P H HoNagendran RamalingamThibaut ImberdisErin C WilkieUlf DettmerDennis J Selkoe

Published in: Movement disorders : official journal of the Movement Disorder Society (2020)

Our findings demonstrate a novel link between the fundamental process of palmitoylation and αS pathophysiology. Upregulating palmitoylation represents an unexplored therapeutic strategy for synucleinopathies. © 2020 International Parkinson and Movement Disorder Society.

Keyphrases

poor prognosis
cell proliferation
signaling pathway
radiation induced
radiation therapy