Chitosan-Stabilized Selenium Nanoparticles Alleviate High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease (NAFLD) by Modulating the Gut Barrier Function and Microbiota.
Yuhang LuoShujiang PengJintao ChengHongli YangLin LinGuiling YangYuanxiang JinQingchi WangZhengshun WenPublished in: Journal of functional biomaterials (2024)
Low molecular weight chitosan selenium nanoparticles (LCS-SeNPs), a biologically active compound derived from selenium polysaccharides, have demonstrated potential in addressing obesity. However, the mechanism through which LCS-SeNPs alleviate high-fat diet (HFD)-induced non-alcoholic fatty liver disease (NAFLD) remains unclear. Our results elucidated that LCS-SeNPs significantly inhibited fat accumulation and markedly improved the intestinal barrier by increasing mucus secretion from goblet cells. Moreover, LCS-SeNPs reshaped intestinal flora composition by increasing the abundance of mucus-associated microbiota ( Bifidobacterium , Akkermansia , and Muribaculaceae_unclassified ) and decreasing the abundance of obesity-contributed bacterium ( Anaerotruncus , Lachnoclostridium , and Proteus ). The modulation of intestinal microbiota by LCS-SeNPs influenced several metabolic pathways, including bile acid secretion, purine metabolites, and tryptophan derivation. Meanwhile, glycocholic acid and tauro-beta-muricholic acid were significantly reduced in the LCS-SeNP group. Our study suggests the crucial role of intestinal microbiota composition and metabolism, providing a new theoretical foundation for utilizing selenium polysaccharides in the intervention of HFD-induced NAFLD.
Keyphrases
- high fat diet
- insulin resistance
- high fat diet induced
- adipose tissue
- metabolic syndrome
- skeletal muscle
- high glucose
- drug delivery
- type diabetes
- diabetic rats
- randomized controlled trial
- induced apoptosis
- antibiotic resistance genes
- weight loss
- endothelial cells
- wound healing
- weight gain
- liver fibrosis
- microbial community
- oxidative stress
- walled carbon nanotubes
- stress induced
- body mass index