Colorectal cancer incidences in Lynch syndrome: a comparison of results from the prospective lynch syndrome database and the international mismatch repair consortium.
Pål MøllerToni SeppäläJames G DowtySaskia HauptMev Dominguez-ValentinLone SundeInge BernsteinChristoph EngelStefan AretzMaartje NielsenGabriel CapellaDafydd Gareth EvansJohn BurnElke Holinski-FederLucio BertarioBernardo BonanniAnnika LindblomZohar LeviFinlay MacraeIngrid WinshipJohn-Paul PlazzerRolf SijmonsLuigi LaghiAdriana Della ValleKarl HeinimannElizabeth HalfFrancisco Lopez-KoestnerKarin Alvarez-ValenzuelaRodney J ScottLior KatzIdo LaishElez VainerCarlos Alberto VaccaroDirce Maria CarraroNathan GluckNaim Abu-FrehaAine StakelumRory KennellyDes WinterBenedito Mauro RossiMarc GreenblattMabel BohorquezHarsh ShethMaria Grazia TibilettiLeonardo S Lino-SilvaKaroline HorisbergerCarmen PortenkirchnerIvana NascimentoNorma Teresa RossiLeandro Apolinário da SilvaHuw ThomasAttila ZarándJukka-Pekka MecklinKirsi PylvänäinenLaura Renkonen-SinisaloAnna LepistoPäivi PeltomäkiChristina TherkildsenLars Joachim LindbergOle Thorlacius-UssingMagnus von Knebel DoeberitzMarkus LoefflerNils RahnerVerena Steinke-LangeWolff SchmiegelDeepak VangalaClaudia PerneRobert HüneburgAída Falcón de VargasAndrew LatchfordAnne-Marie GerdesAnn-Sofie BackmanCarmen Guillén-PonceCarrie SnyderCharlotte K LautrupDavid AmorEdenir PalmeroElena StoffelFloor DuijkersMichael J HallHeather HampelHeinric WilliamsHenrik OkkelsJan LubińskiJeanette ReeceJoanne NgeowJose G GuillemJulie ArnoldKarin WadtKevin MonahanLeigha SenterLene J RasmussenLiselotte P van HestLuigi RicciardielloMaija R J Kohonen-CorishMarjolijn J L LigtenbergMelissa SoutheyMelyssa AronsonMohd N ZaharyN Jewel SamadderNicola PoplawskiNicoline HoogerbruggePatrick J MorrisonPaul JamesGrant LeeRakefet Chen-ShtoyermanRavindran AnkathilRish PaiRobyn WardSusan ParryTadeusz DębniakThomas JohnThomas van Overeem HansenTrinidad CaldésTatsuro YamaguchiVerónica Barca-TiernoPilar GarreGiulia Martina CavestroJürgen WeitzSilke RedlerReinhard BüttnerVincent HeuvelineJohn L HopperAung Ko WinNoralane LindorSteven GallingerLoïc Le MarchandPolly A NewcombJane FigueiredoDaniel D BuchananStephen N ThibodeauSanne W Ten BroekeEivind HovigSigve NakkenMarta PinedaNuria DueñasJoan BrunetKate GreenFiona LallooKatie NewtonEmma J CrosbieMiriam MintsDouglas TjandraFlorencia NeffaPatricia EsperonRevital KarivGuy RosnerWalter Hernán PavicicPablo KalfayanGiovana Tardin TorrezanThiago BassanezeClaudia MartinGabriela MosleinAysel AhadovaMatthias KloorJulian R SampsonMark A Jenkinsnull nullPublished in: Hereditary cancer in clinical practice (2022)
Prospectively observed CRC incidences (PLSD) in path_MLH1 and path_MSH2 carriers undergoing colonoscopy surveillance and polypectomy were higher than in the retrospective (IMRC) series, and were not reduced in path_MSH6 carriers. These findings were the opposite to those expected. CRC point incidence before 50 years of age was reduced in path_PMS2 carriers subjected to colonoscopy, but not significantly so.