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Epigenetic dynamics shaping melanophore and iridophore cell fate in zebrafish.

Hyo Sik JangYujie ChenJiaxin GeAlicia N WilkeningYiran HouHyung Joo LeeYou Rim ChoiRebecca F LowdonXiaoyun XingDaofeng LiCharles K KaufmanStephen L JohnsonTing Wang
Published in: Genome biology (2021)
Pigment cell fate is marked by substantial DNA demethylation events coupled with dynamic chromatin accessibility to potentiate gene regulation through cis-regulatory control. Here, we provide a multi-omic resource for neural crest differentiation into melanophores and iridophores. This work led to the discovery and validation of iridophore-specific alx4a transcription factor.
Keyphrases
  • cell fate
  • transcription factor
  • gene expression
  • dna binding
  • dna methylation
  • small molecule
  • circulating tumor
  • single molecule
  • genome wide identification
  • dna damage
  • genome wide
  • nucleic acid