Epigenetic dynamics shaping melanophore and iridophore cell fate in zebrafish.
Hyo Sik JangYujie ChenJiaxin GeAlicia N WilkeningYiran HouHyung Joo LeeYou Rim ChoiRebecca F LowdonXiaoyun XingDaofeng LiCharles K KaufmanStephen L JohnsonTing WangPublished in: Genome biology (2021)
Pigment cell fate is marked by substantial DNA demethylation events coupled with dynamic chromatin accessibility to potentiate gene regulation through cis-regulatory control. Here, we provide a multi-omic resource for neural crest differentiation into melanophores and iridophores. This work led to the discovery and validation of iridophore-specific alx4a transcription factor.