Shift in VEGFA isoform balance towards more angiogenic variants is associated with tumor stage and differentiation of human hepatocellular carcinoma.

Mikhail S ChesnokovPolina A KhesinaDarya A ShavochkinaInna F KustovaLeonid M DyakovOlga V MorozovaNikolai S MugueNikolay E KudashkinEkaterina A MorozYuri I PatyutkoNatalia L Lazarevich

Published in: PeerJ (2018)

A distinct shift in VEGFA isoform balance towards more pro-angiogenic variants occurs in HCC tissue and may modulate overall impact of VEGFA signaling. We suppose that the ratio between VEGFA isoforms is an important parameter governing HCC angiogenesis that may affect HCC progression and be used for optimizing the strategy of HCC therapy by predicting the response to anti-angiogenic drugs.

Keyphrases

endothelial cells
copy number
gene expression
vascular endothelial growth factor
bone marrow
mesenchymal stem cells
cell therapy
pluripotent stem cells
wound healing