Double Trouble: Whole-Genome Doubling Distinguishes Early from Late Ovarian Cancer.

Shih Yu Cindy YangTrevor J Pugh Amit M Oza

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2022)

Dramatic differences in outcome between early- and late-stage high-grade serous ovarian cancer (HGSC) suggest perhaps distinct genetic origins due to differences in exposures to mutational processes. Evidence to support this hypothesis was recently reported by comparative analysis of copy-number signatures between early- and late-stage HGSCs. See related article by Cheng et al., p. 2911.

Keyphrases

copy number
high grade
genome wide
mitochondrial dna
low grade
dna methylation
air pollution
gene expression