RE-ORGA, a Korean Herb Extract, Can Prevent Hair Loss Induced by Dihydrotestosterone in Human Dermal Papilla Cells.

Myung-Gyun Kang Daeui Park Hyoung-Yun Han Hyeeun Shim Yoonjung Hong Jiyeon Moon Seokjoo Yoon Bosun Kwon

Published in: Annals of dermatology (2019)

Transcriptionally, up-regulation of PTK2β and concomitant down-regulation of TGFβ1I1 imply that RE-ORGA can modulate androgen receptor sensitivity, decreasing the expression of 5α-reductase type II and Bax together with TGF-β1 transcripts; RE-ORGA also showed partial anti-inflammatory activity. Overall, RE-ORGA is expected to alleviate hair loss by regulating 5α-reductase activity and the receptor's androgen sensitivity.

Keyphrases

induced apoptosis
transforming growth factor
endothelial cells
oxidative stress
poor prognosis
endoplasmic reticulum stress
cell cycle arrest
signaling pathway
binding protein
induced pluripotent stem cells
long non coding rna