ARPC1A correlates with poor prognosis in prostate cancer and is up-regulated by glutamine metabolism to promote tumor cell migration, invasion and cytoskeletal changes.
Ye-Hui ChenHang ChenTing-Ting LinJun-Ming ZhuJia-Yin ChenRu-Nan DongShao-Hao ChenFei LinZhi-Bin KeJin-Bei HuangYong WeiQing-Shui ZhengXue-Yi XueNing XuPublished in: Cell & bioscience (2023)
These findings suggested that ARPC1A, which correlates with poor prognosis in PCa, functions downstream of glutamine metabolism to regulate cytoskeletal changes, cellular migration and cellular invasion in this disease.