Towards a biomarker model for cognitive improvement: No change in memory-related prefrontal engagement following a negative cognitive remediation trial in bipolar disorder.
Julian MacoveanuKirsa M DemantMaj VinbergHartwig R SiebnerLars V KessingKamilla W MiskowiakPublished in: Journal of psychopharmacology (Oxford, England) (2018)
As hypothesized, no task-related change in prefrontal activity was observed in a negative cognitive remediation trial in remitted bipolar disorder patients. By complementing previous findings linking cognitive improvement with increased dorsolateral prefrontal cortex engagement, our negative findings provide additional validity evidence to the dorsal prefrontal target engagement biomarker model of cognitive improvement by strengthening the proposed causality between modulation of dorsolateral prefrontal cortex engagement and pro-cognitive effects.
Keyphrases
- prefrontal cortex
- bipolar disorder
- working memory
- transcranial magnetic stimulation
- social media
- major depressive disorder
- clinical trial
- functional connectivity
- study protocol
- ejection fraction
- randomized controlled trial
- newly diagnosed
- high frequency
- phase ii
- transcranial direct current stimulation
- prognostic factors
- open label
- double blind