Possible involvement of DExD/H box helicase 60 in synovial inflammation of rheumatoid arthritis: role of toll-like receptor 3 signaling.
Yuzuru NakamuraHikaru Kristi IshibashiTatsuro SarugaTadaatsu ImaizumiAkira KuroseMayuki TachizakiShogo KawaguchiKazuhiko SeyaEiji SasakiYasuyuki IshibashiPublished in: Molecular biology reports (2024)
The synovial DDX60 was more expressed in RA patients than in OA. In human RFLS, DDX60 stimulated by TLR3 signaling affected CXCL10 expression. DDX60 may contribute to synovial inflammation in RA.
Keyphrases
- toll like receptor
- rheumatoid arthritis
- inflammatory response
- nuclear factor
- disease activity
- oxidative stress
- end stage renal disease
- immune response
- endothelial cells
- newly diagnosed
- ejection fraction
- ankylosing spondylitis
- chronic kidney disease
- poor prognosis
- binding protein
- interstitial lung disease
- prognostic factors
- peritoneal dialysis
- systemic lupus erythematosus
- patient reported outcomes
- systemic sclerosis
- knee osteoarthritis