Protective Role of Taurine on Rat Offspring Hypertension in the Setting of Maternal Chronic Kidney Disease.
You-Lin TainChih-Yao HouGuo-Ping Chang-ChienSufan LinChien-Ning HsuPublished in: Antioxidants (Basel, Switzerland) (2023)
Taurine is a natural antioxidant with antihypertensive properties. Maternal chronic kidney disease (CKD) has an impact on renal programming and increases the risk of offspring hypertension in later life. The underlying mechanisms cover oxidative stress, a dysregulated hydrogen sulfide (H 2 S) system, dysbiotic gut microbiota, and inappropriate activation of the renin-angiotensin-aldosterone system (RAAS). We investigated whether perinatal taurine administration enables us to prevent high blood pressure (BP) in offspring complicated by maternal CKD. Before mating, CKD was induced through feeding chow containing 0.5% adenine for 3 weeks. Taurine was administered (3% in drinking water) during gestation and lactation. Four groups of male offspring were used ( n = 8/group): controls, CKD, taurine-treated control rats, and taurine-treated rats with CKD. Taurine treatment significantly reduced BP in male offspring born to mothers with CKD. The beneficial effects of perinatal taurine treatment were attributed to an augmented H 2 S pathway, rebalance of aberrant RAAS activation, and gut microbiota alterations. In summary, our results not only deepen our knowledge of the mechanisms underlying maternal CKD-induced offspring hypertension but also afford us the impetus to consider taurine-based intervention as a promising preventive approach for future clinical translation.
Keyphrases
- chronic kidney disease
- blood pressure
- end stage renal disease
- high fat diet
- oxidative stress
- drinking water
- birth weight
- diabetic rats
- pregnancy outcomes
- pregnant women
- hypertensive patients
- randomized controlled trial
- heart rate
- preterm infants
- adipose tissue
- high glucose
- insulin resistance
- drug induced
- health risk assessment
- endothelial cells
- type diabetes
- combination therapy
- blood glucose
- health risk
- skeletal muscle
- human milk
- arterial hypertension
- low birth weight
- smoking cessation