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Characterization of a novel HDAC/RXR/HtrA1 signaling axis as a novel target to overcome cisplatin resistance in human non-small cell lung cancer.

Wenjing WangMengyue ZhaoLijuan CuiYong RenJingyuan ZhangJunli ChenLina JiaJiayu ZhangJingyu YangGuoliang ChenCharles R AshbyChunfu WuZhe-Sheng ChenLihui Wang
Published in: Molecular cancer (2020)
Our results indicate that HtrA1, a cisplatin resistance-related gene, is synergistically regulated by HDAC and RXR in NSCLC. Targeting the HDAC/RXR/HtrA1 signaling axis can rescue HtrA1 expression and reverse cisplatin resistance in NSCLC.
Keyphrases
  • small cell lung cancer
  • histone deacetylase
  • endothelial cells
  • advanced non small cell lung cancer
  • poor prognosis
  • gene expression
  • copy number
  • cancer therapy
  • brain metastases
  • drug induced