Characterization of a novel HDAC/RXR/HtrA1 signaling axis as a novel target to overcome cisplatin resistance in human non-small cell lung cancer.
Wenjing WangMengyue ZhaoLijuan CuiYong RenJingyuan ZhangJunli ChenLina JiaJiayu ZhangJingyu YangGuoliang ChenCharles R AshbyChunfu WuZhe-Sheng ChenLihui WangPublished in: Molecular cancer (2020)
Our results indicate that HtrA1, a cisplatin resistance-related gene, is synergistically regulated by HDAC and RXR in NSCLC. Targeting the HDAC/RXR/HtrA1 signaling axis can rescue HtrA1 expression and reverse cisplatin resistance in NSCLC.