Characterization of a novel HDAC/RXR/HtrA1 signaling axis as a novel target to overcome cisplatin resistance in human non-small cell lung cancer.

Wenjing WangMengyue ZhaoLijuan CuiYong RenJingyuan ZhangJunli ChenLina JiaJiayu ZhangJingyu YangGuoliang ChenCharles R AshbyChunfu WuZhe-Sheng ChenLihui Wang

Published in: Molecular cancer (2020)

Our results indicate that HtrA1, a cisplatin resistance-related gene, is synergistically regulated by HDAC and RXR in NSCLC. Targeting the HDAC/RXR/HtrA1 signaling axis can rescue HtrA1 expression and reverse cisplatin resistance in NSCLC.

Keyphrases

small cell lung cancer
histone deacetylase
endothelial cells
advanced non small cell lung cancer
poor prognosis
gene expression
copy number
cancer therapy
brain metastases
drug induced